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KMID : 0043320070300081014
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Archives of Pharmacal Research
2007 Volume.30 No. 8 p.1014 ~ p.1019
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A Novel Nasal Delivery System of a Chinese Traditional Medicine, Radix Bupleuri, Based on the Concept of Ion-Activated in Situ Gel
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Cao Shi-Lei
Chen En
Zhang Qi-Zhi
Jiang Xin-Guo
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Abstract
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The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 mPa·s and caproic acid content of 1.31± 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly (1.1oC at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.
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KEYWORD
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Radix Bupleuri, In situ gel, Gellan gum, Antipyretic effect
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